Which graft involves tissue transplanted between different species?

Which graft involves tissue transplanted between different species?

• A. Xenograft
• B. Allograft
• C. Autograft
• D. Isograft

Answer: (A)

Xenograft. Tissue transplanted between different species triggers a strong immune reaction because the donor’s antigens are markedly different from the recipient’s, leading to rapid rejection unless substantial immune suppression or tissue modification is used. This distinguishes it from an allograft (same species, different individual), an autograft (tissue from the same person), and an isograft (genetically identical individuals, such as identical twins). The cross-species barrier is the key challenge with xenografts, which is why they are much more difficult to succeed with clinically compared to grafts within the same species.

Xenograft. Tissue transplanted between different species triggers a strong immune reaction because the donor’s antigens are markedly different from the recipient’s, leading to rapid rejection unless substantial immune suppression or tissue modification is used. This distinguishes it from an allograft (same species, different individual), an autograft (tissue from the same person), and an isograft (genetically identical individuals, such as identical twins). The cross-species barrier is the key challenge with xenografts, which is why they are much more difficult to succeed with clinically compared to grafts within the same species.